Short answer is NO.
Within interstellar space or within our local solar system, aerodynamics isn't going to make much of a difference. And from @PearsonArtPhoto's calculations, at the speed at which they DO make a difference, the particles are going to ram into the probe with enough energy to erode the outer-surface. Gases and particles in interstellar space are often ionized (i.e. charged) and some atoms are very hot. It is akin to driving a car at 100mph through a dust-cloud - your windshield is going to be poc-marked and if one drove long enough, it might crack and fail.
With that in mind, you'd want to make the cross-section of a ship small to deal with erosion more than aerodynamics. Probably made of thick and durable material, and ideally shielded somehow - possibly with a magnetic field to help push particles away from the ship.
Have a look at: http://en.wikipedia.org/wiki/Interstellar_medium for a bit more detail.
For a real-world example, Voyager 1 - traveling at a brisk 17 Kilometers per SECOND away from the sun isn't very aerodynamic at all. Big clunky right angles, a giant radio dish on the back, etc.