Well, no. Way too expensive. What SpaceX is doing now is probably the best option but ...
The long slender Saturn 5 had major issues with harmonic oscillation under its massive thrust. This is one of the reasons why the shorter, chunkier Space Shuttle design followed on.
The Space Shuttle designeddesign was hamstrung by the need to recover the main engines, which resulted in a gigantic orbiter with limited cargo dimensions.
These days, we can recover boosters, which frees up orbiters to a far more sensible configuration of separate shuttle (second stage) and extremely flexible (you name it) third stage/cargo/manned shuttle design.
Ironically, the Saturn 5 second stage could have been a winged shuttle with only minor modifications. But SpaceX may have some hard lessons to learn about long, slender rocket designs.
The mighty Saturns were a tremendous technological achievement in their time, but are being superseded by today's technology.