In a sense it does. Public safety is more of an absolute requirement as opposed to something that you attempt to maximize. When comparing a flight plan that reenters over the Indian Ocean to a flight plan that renters over the Pacific Ocean, its is quite possible that the Indian Ocean flight plan had acceptable risk and the Pacific Ocean flight plan did not.
For the Pacific flight plan to qualify, they would need to establish that: a) The rocket had enough delta-v to reach that sub-orbital trajectory (assuming that all of its systems performed nominally), and b) That there was a plan to safely abort if at any point the mission became off-nominal. Aborting might involve, for example, initiating the flight termination system at a point in time when the rocket's trajectory would ensure that the debris would reenter and fall into an ocean, such as the Indian Ocean, as opposed to on land.
With the Pacific flight plan, once the ship has accelerated to the point where its sub-orbital trajectory ends in the Indian Ocean, the systems on board would need to make a choice - either continue the burn to completion to move the trajectory's termination point further downrange and over the Pacific Ocean, or terminate the burn while the trajectory's termination point still ends somewhere over the Indian Ocean. An in-between termination point would not be acceptable as it might lead to debris coming down over populated land.
For the Pacific Ocean flight plan to have unacceptable risk, the probability of the ship being able to continue its burn to completion would need to be high. There are a few things that could still go wrong during the final moments of that burn. The ship could simply run out of propellant or the ship could break up due to the ever-increasing acceleration. Note that the ship is lightest when its tanks are near empty; therefore, its acceleration is at its highest. Pressures at the bases of header pipes would be peaking at this point as well as stresses within some parts of the ship's structure.
If you'd like to learn more about how the Expected Casualty ($E_c$) rates for commercial space launch and reentry missions are evaluated, there is an FAA advisory on this topic. But also keep in mind that even if it could be shown mathematically that the probability of debris coming down over land and physically harming someone is extremely low, allowing any debris to come down anywhere near land could be damaging from a public relations point of view. SpaceX needs to consider not only the mathematically calculated public safety but also the public's perception of public safety.
Update
@TheRocketFan included images (in their now-deleted answer) that Jonathan McDowell posted on X. I think that they are useful and so I've added them here. The first two show the estimated flight path proposed for the first 2 missions and the last shows the estimated flight path proposed for IFT3.
Source of the images: