In addition to the benefits of smaller and more frequent launches (and perhaps other benefits), could fuel depots also provide a modest benefit in reducing the mass of fuel tanks for vehicles leaving LEO?
This assumes that stresses on fuel tanks during the trip to LEO would be reduced by not being loaded with fuel, that stresses from LEO outward are lower, and that support for any inflation or other reconstruction in LEO would not add mass that must be carried out of LEO. (Any extra mass that is left in LEO would still be an issue.)