For a number of reasons human reasons like giving someone astronaut wings, winning the X prize or for rules around national boundaries there is a need for a hard divider between 'space' and 'atmosphere' and the calculations for the Karman line provide a convenient mathematical way to do that. The fact that the Karman line of 100km used for most purposes is actually some distance from the ~85km point that Karman calculated is possibly telling in terms of how meaningful the value is other than it being a round number higher than aircraft can fly and lower than space craft can sensibly sustain orbit.
So the Karman line is a legal construct for space law and administration, and almost meaningless for actual engineering.