With few exceptions, orbit-reaching rocket systems have a service life limited to a single launch.
The Space Shuttle was intended at concept to be highly (and economically) reusable. Although much of the vehicle was reusable, it took a lot of work and money to prepare the vehicle for its next flight. Ultimately, its reusability was not economically advantageous.
The current SpaceX Falcon 9 is claimed to require no refurbishment from soft landing to next launch. Even if the claim is inflated, it is presumably less expensive per unit of payload to re-fly than the Shuttle ever was.
My question is: what is the current state-of the art for reusable surface-to-orbit vehicle systems where reuse actually confers an economic advantage over a non-reusable vehicle of comparable capacity? How many flights until either end-of-life or major refurbishment for the highest-wear components (rocket nozzles, re-entry thermal protection, etc.)? Does it number in the tens, hundreds, or perhaps thousands?
Even if the main structure and systems of a given vehicle are fully reusable, would it be more economic to manufacture high-wear items like rocket nozzles, heat shields, etc. to be "single-use"/disposable than to engineer them for maximum lifetime?