Staying in space is different from staying on Earth. When astronauts return to Earth from orbit, they usually suffer from muscle loss.
Are there any genetic (abnormal) changes in their cells or in their offspring?
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It depends on amount of time astronauts spend in space, as DNA changes are as more probable as more radiation the body receives, and spacesuits, and habitat themselves, offer much less radiation shieldeing than earth atmosphere: ISS radiation shielding is 1/100 of Earth atmosphere shielding (10g/cm2 vs 1000 g/cm2); Apollo space suits offered just 1/10000 of Earth shielding (don't know about current spacesuits)