Is there a NASA or a Roscosmos safety guidelines or something, stating the minimum crew required to safely operate the TMA-M? I.e. get it into orbit and safely re-enter.
In theory 0, as the spacecraft can be remotely controlled by the Teleoperated Control Mode present in all Soyuz spacecraft. This has not been used beyond a few rendezvous tests though, so an onboard pilot is still recommended.