If there is a wall between a pressurised room and a vacuum, the resulting forces to the wall are pretty strong. Strings of a guitar sound different if tension on the string varies. I suspect the wall would sound different. The force on a door between vacuum and pressure is so strong that opening of the door would be impossible or the door is severly damaged.
I have seen a normal room door bending by a pressure difference between both adjacent rooms. The pressure difference was very small, only some centimeters of water or a few mbar. It was possible to open the door, but you had to use all your muscles.
The force to a door 1 m wide and 2 m high from a pressure difference of 1 bar is the same as of a load of 20,000 kg to the ground below. It is better to build not a rectangular door but a circular one.