If you build a space station in the shape of a cylindrical wheel and construct it so that it spins around a central docking point in order to create artificial gravity would it be logical to orient the interior structures so that the crew would have their feet aligned with the centripetal force (i.e., parallel to the radius of the circle)?
If we ignore the shape you decide to go with for the moment, yes, of course you want interior structures aligned so that "down" as perceived by the crew is the same as the "down" direction something would fall when dropped. This way things on a desk will stay there, for example.
So for a cylindrical wheel, the curved floor will be the skin of the cylinder.
I am unsure what you mean by "aligned parallel to the radius of the circle" though.