It is well-known that the lack of gravity during spaceflight is a cause to many sorts of health issues.
It is thus expected that Martian gravity (significantly lower than Earth's) will have influence on humans. Especially if the perspective of long-term missions is considered.
Would it be worth considering to let humans sleep in some sort of centrifuges?
By this means, during sleep time, the human body could partly recover from the exposure to low gravity. The artificial gravity would be smoothly ramped up and down. It could be adjusted to various levels, so that the optimum could be identified experimentally.