Note: @Conelisinspace's comment reminds me that the clouds don't begin at the surface. Double checking the plot, this happens at roughly ~30 km, at which point the pressure is almost 10x lower, but the (absolute) temperature drops by almost a factor of 2 as well, so we can't quite say we're above 90% of the mass.
However, even if we could, the temperature rise of 0.0001 C would only increase to 0.001 C when a 100 megaton output is averaged over a 1,000 km diameter window, so it still is a half-dozen orders of magnitude away from boiling the water droplets necessary to turn clouds and (presumably) haze transparent. No change in conclusion.
No, not even close.
These devices don't "blow holes" in the atmosphere, they heat the atmosphere and it expands. So your only chance is to heat it so much that the droplets making it totally opaque are vaporized, turning the atmosphere back into a gas rather than a giant, thick cloud.
According to NASA's fact sheet for Venus the scale height of Venus' atmosphere is about 16 km, which means the density drops with altitude much more slowly than with Earths's ~8 km scale height, combining that with the fact that it starts at 90 times higher density, this explains why the total mass of Venus' atmosphere of about 5E+20 kg is 100 times larger than that of Earth's.
1 ton (of TNT equivalent) is 1 gigacalorie, or 4.184 gigajoules. Let's say you use a really really huge 100 megaton thermonuclear bomb. I don't know if you can get them that big these days. Amazon certainly doesn't carry them.
That's 1E+08 * 4E+09 = 4E+17 Joules, or about 1 miliJoule per kilogram of atmosphere. That's not much. A 500 km radius on the planet has an area of 8E+05 km^2, which is 0.2% of Venus' total area of 4.5E+08 km^2.
That means detonating such a bomb would add about 0.5 Joule per kg of atmosphere in that 1,000 km diameter circle, which would heat it by maybe 0.0001C. Essentially Nothing. No change whatsoever.
It might make a temporarily transparent "bubble" near the surface with a radius of the order of 1 km, that includes only 1 km up as well as to the sides. But no chance that that the atmosphere would be affected all the way to the top.