I'll admit that the manned aspect of the following program is fairly tangential to its main goals, but it is something, and the company could become a major player in the SSTO market within the next decade or so.
I'm talking about Reaction Engines. They're an English group primarily concerned with the Skylon spaceplane. It's original design was unmanned, but there have been some side efforts to put a passenger module in the payload bay. It's unclear as to whether the craft would still be autonomous; I would think so because there would be a massive design challenge to make it pilotable.
From their website:
Reaction Engines Ltd ('REL') is a privately held company located in the United Kingdom and was formed in 1989 to develop the technologies needed for an advanced combined cycle air-breathing rocket engine class called SABRE that will enable aircraft to operate easily at speeds of up to five times the speed of sound or fly directly into Earth orbit.
According to Wikipedia, the group aims to have the first test flights in 2019.
Some of the company's other projects include the SABRE engine and the group's LAPCAT design. Wikipedia goes into some detail about their entrance in that (called the A2), but I can't verify that information from the company's official website. The A2 would definitely be manned, but it would not be capable of even sub-orbital flight, nor is it designed to do that.