Answer: Routine preventative appendectomy is a bad idea.
Preventative appendectomy can only be advised if there is a net benefit. To determine this, the risks of preventative appedectomy need to be determined as well as effectiveness of non- surgical treatment.
It is easy (but not necessarily true) to assume that
- preventative appendectomy is harmless
- acute appendicitis is fatal without surgery.
- the appendix is useless and there is no downside to removing it even if healthy.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502196 is a good review on conservative (non-operative) treatment of appendicitis. There have been numerous studies conducted on this by the military and fishing fleets. There have been several large series (200-500 patients) treated by antibiotics alone.
In this study, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502196, patients with acute appendicitis were treated with high dose antibiotics. Only one patient in 20 failed to respond to antibiotics alone and required surgery.
Complications of appendectomy include a lifetime increase risk of surgery for bowel obstruction (1.1% in the 5 years after surgery). https://www.hopkinsmedicine.org/health/conditions-and-diseases/appendicitis#:~:text=Appendicitis%20affects%201%20in%201%2C000,the%20risk%20of%20getting%20appendicitis .
The annual risk of appendicitis is 1:1000. So if you do 1000 preventative appendectomies, you would cause 11 surgical cases of potentially fatal bowel obstruction, just to prevent one case of appendicitis.
And what of that single case of appendicitis which could have been prevented by operating on a thousand healthy people? If that appendicitis case is treated promptly with high dose antibiotics, it has a 95% chance of a cure.
The argument for preventative appendectomy is not looking good. Suppose you are heading to Mars and are offered a farewell appendectomy. There is a 1% chance of developing a potentially fatal bowel obstruction following surgery. If you don’t have the appendectomy, you have a <0.01% chance of dying from appendicitis which failed to respond to antibiotics.