Not original, but close.
If we view the original hi-res photo used in the question we can see the salmon color behind crew member Ellen Ochoa. This tells us that the hatch in question is the Node 1 aft hatch (it leads to the Russian module FGB).
We can see in this photo from STS-88, the first Shuttle ISS assembly flight, that the same hatch is not yet decorated with the signs.
The signs appear on the next mission, STS-96. They have not yet been affixed in this photo. I note that some of the signs are differently colored from the question in the photo (which was taken on STS-110), so they may have been replaced at a later date. A brief review of other missions does not show the signs permanently in place until STS-110, Ellen Ochoa's next mission to the ISS. Perhaps she was the creator of the signs.
Images from the old, mostly abandoned, NASA site nasa.spaceflight.gov.