Perhaps this seems trivial, since it may not directly affect our planet, but if we ever colonize the Moon and mine its resources, the trace of human devastation will change sooner or later the surface of the moon, and will be even visible from Earth. Not to mention that any geological features still worth studying could be destroyed (we have the human impact on our planet in the last 200 years as an example).
Is there any feature with either scientific, cultural or historical value to be protected? Is any single spot on the moon open for mining/colonization?