NASA released a manual control requirements white paper for the Integrated Human Lunar Lander (IHLL) as part of their Appendix H Broad Agency Announcement (BAA). It can be found here: https://www.fbo.gov/notices/5491073942d867e576fbb1acc32bb8d2 as Attachment A17.
I found it to be an interesting read and it covers manual control actions during different mission phases. Manual control will likely not only be unnecessary but also unwanted during any transition burn or free-flight situations, but any docking (crewed refueling) and Mars landing situations will require a human to be able to be in the loop. Human control avoided multiple LOC events on Apollo and will likely still be required for decades in the future.
I want to let others draw their conclusions from this paper, but selecting from pre-programmed subroutines is explicitly considered to not be manual control. Manual control is a pilot literally grabbing the stick and having control of at least the descent rate and translation of the spacecraft during landing, and the attitude during docking.