What component, if any, would cause irreparable harm ("total") the ISS if it were to break or require replacement? If this component exists, when is it going to reach its end-of-life?
By "total", I mean that it would be cheaper to build a new space station rather than repair or replace the broken component. Also, since this hypothetical repair might go into Ship of Theseus territory, I would consider the ISS to have been "totaled" if it's given a new name afterwards, like ISS2 instead of ISS.