I mean launch from Earth, dock to the gateway and come back.
They would require another vehicle to provide the delta-v to get to the moon and then to return. So by themselves no.
Assuming some sort of additional stage were launched then they would need a beefed up heat shield for the higher energy reetry speed. (Or else some other method of slowing down, like using the additional stage to capture into Earth orbit, wasting delta-v/fuel/etc).