Orion is designed to land in the ocean and is therefor not reusable after landing (only some internal systems will be reused). But can Orion be reused while in space? What would the main issues be?
Could it for example be used as a shuttle between ISS and the captured asteroid in the ARM mission? The crew would land with Soyuz or DragonRider. The propulsion stage of Orion would be refueled and its crew will be supplied as two or more out of the regular ISS crew. Or as a shuttle between ISS and a (BA330?) station orbiting the Moon, from which the crew lands on the Moon with a modified DragonRider?