Barycenter is just another name for center of mass, although usually in the context of orbiting bodies. At a large distance from all the bodies in a system, the gravitational field can be approximated as coming from a point source positioned at the barycenter and containing the total mass of the system. However, this approximation is not useful inside the system. In this case, the individual fields (and their directions) from each body have to be calculated and summed.
Since the Sun-Earth L2 is well inside the solar system, the solar system barycenter is not useful. The Earth/Moon does not orbit around the solar barycenter. It orbits around the Sun with perturbations from Jupiter and the other planets.
The Earth/Moon barycenter is a little more relevant. L2 is at a distance four times the size of the Earth/Moon system. Between the two extremes of its orbit, the Moon is either 25% closer to L2 or 25% further from L2. The gravitational field from the Moon is either 56% stronger or 44% weaker - which seems a lot . However the Moon has only 1/80th the mass of the Earth, so its not that bad an approximation, the error is only around 0.5%.
The spacecraft trajectory from Earth to L2 is certainly calculated numerically summing the individual fields from the Earth, the Moon, the Sun, and probably Jupiter and any other significant graviational sources in the solar system. The positions of the these bodies at the time of launch will be important, particulary the position on the Earth and the positions of the Sun and Moon which are obviously very important.
The Earth/Moon barycenter as an approximate field source during stationkeeping could be helpful. But, again, my guess is that the real fields from the relevant bodies are calculated plus the estimated solar pressure and these are all summed. With the tools and computational capabilities available nowadays. these calculations are straightforward.
In conclusion, the answer is no. The solar system barycenter is not relevant at all and direct calculations of the fields are easy enough and so much more accurate that using the Earth/Moon barycenter as an approximation would not be helful either.