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It is well known that there are a number of negative health issues (loss of bone density, muscle mass, eyesight degeneration, etc.) that can impair astronauts who spend long periods of time in space. That said, are there no positive effects on the human body at all?

Edit: To address the comments, let's assume that the astronauts are eventually going to return to Earth.

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    $\begingroup$ Hard vacuum will prevent decomposition prior to the return trip home. $\endgroup$ – Erik Dec 8 '14 at 7:52
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There have been no known long-term positive health effects reported.

Then again, euphoria and elation are considered negative health effects, and both have been reported, and many other causes are used as recreational stress relief.

Almost all astronauts report positive mental attitude changes from their time in orbit. This isn't exactly measurable, tho', and I've not seen any well done studies done on Astronauts who flew versus those who didn't on various psychological effects. †

Short term, ISTR reading that blood pressure generally drops. And there is a study reporting that blood pressure and heart rate drop while in microgravity. ①. This does, however, appear to be maladaptive for return, as it also is accompanied by cardiac atrophy.

Into the Realm of Wild Speculation.

This reduction could be of use for certain individuals at grave risk of stroke or heart attack from hypertension; the reduction in blood pressure and heart rate is known to be a direct reduction in stroke and heart attack risks. The problem being that current launch protocols involve a highly stressful period of increased workload for launch, which is counter-indicated by the very condition which would benefit from the reduction. ‡

Certain forms of depression might benefit from spaceflight and microgravity. The profound "life changing experience" reported by almost all astronauts may be of benefit, but until it is more affordable, it's unlikely to be tested.


References

① Microgravity decreases heart rate and arterial pressure in humans.www.ncbi.nlm.nih.gov/pubmed/8964756

Digressions

† The problem being that doing the study is laden with confounding factors and a lack of a viable control group. You'd need a control group who were selectable for astronaut training, but told from the outset they are never going to get to go... Which would be an interesting study in and of itself, but would be impractical financially, might be unethical, and certainly still wouldn't be entirely free of confounding factors.

‡ If some form of gravitic lift is developed, then it's quite likely that this could be of use; it's equally likely that any such lift would render spaceflight unneeded for the same benefit, as any such system would likely be able to generate local microgravity conditions.

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