My friends and I were trying to figure this out a while ago.
I was thinking that by transporting smaller pieces into space via a lighter re-entry spacecraft, there would be overall less fuel used because there would be less "feedback" (ie more fuel needs more fuel to lift that fuel, etc).
My friends were thinking it would be the same because the same overall mass of the craft would require the same amount of fuel.
Would it be more efficient to transport a spacecraft into space in pieces, or only once it is assembled?