Mass fraction and Tsiolkovsky's rocket equation make for major hurdles.
Mf, or the ratio of propellent to dry mass is given by:
$Mf=1-e^{-delta V/V_{exhaust}}$
To climb out of a steep gravity well we need a high thrust propellent. So we use chemical rockets. The $V_{exhaust}$ for the higher ISP chemical propellents is around 4 km/s. Delta V to get to LEO is around 9 km/s.
This sort of delta V combined with Tsiolkovsky's rocket equation means around 90% propellent and 10% dry mass.
Now some of the dry mass budget must go to rocket engines, structure, avionics, power source and payload. So as the delta V budget climbs we're left with fuel tanks about as tenuous as an aluminum coke can.
Shuttle tank photo from NASA
Boost the delta V budget more and you need fueltank walls of cellophane and moon beams.
One of the ways to achieve the mass fractions mandated by the rocket equation is to throw away dry mass enroute: expendable multi-stage rockets.
And then there's re-entry. So now we have a spaceship about as robust as an eggshell re-entering earth's atmosphere at 8 km/s. Re-entry subjects the ship to very extreme conditions: temperatures in 1000s of degrees, dynamic pressure that make a class 5 hurricane look like a gentle breeze.
I give SpaceX better than even odds that they'll reuse a booster stage. If the booster stage has a delta V budet of only 4 or 5 km/s, that allows for a sturdier structure. Also the booster won't be re-entering the atmosphere at orbital velocity.
Re-using a capsule might also be doable. A capsule re-enters the atmosphere at orbital velocity. But it has a low delta V budget. The lower delta V budget allows a mass fraction that permits sturdy structure and Thermal Protection System (TPS).
I give less than even odds the 2nd stage can be re-used. The 2nd stage needs to provide around 8 km/s and needs to re-enter at 8 km/s.
While I give better than even odds that the SpaceX capsule and booster can be re-used, I give a little less than even odds these can be re-used economically. The Space Shuttle re-used some parts but the savings were largely eaten up in refurbishment costs. What will SpaceX refurbishment costs be? this remains to be seen.