Astronauts are highly trained specialists, carefully selected for many characteristics, among them their personality. In many science fiction movies or novels, whole populations travel in space ships for extended periods of time.
Has there been any research, or theoretical extrapolations grounded in research, on how the average person or random samples from the populace deal with prolonged residence in an artificial interior, especially one that does not allow them the oportunity to step "outside" under an open sky.
Bunkers after a nuclear attack, mining accidents, or submarine habitats may fall into the same category, though all situations contain the possibility of reaching the earth's surface.
I am pretty sure even healthy people would develop serious symptoms of claustrophobia, making space travel impossible for most of us.