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Crewed spaceflight (also referred to as human spaceflight or manned spaceflight) is space travel with a crew aboard the spacecraft. When a spacecraft is crewed, it can be operated directly, as opposed to being remotely operated or autonomous.

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What is the largest hurdle of the mission to Mars?

Having discussed this with a couple of people who know it well, seems to me the limiting issue will be human psychology, specifically confined environment psychology, compounded by gerontology and ser …
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