There are some reasons for returning humans to the Moon. They could further the exploration started by the Apollo crews and they could help with construction and maintenance of lunar installations. But thats about it.
The far side of the Moon presents an ideal location for astronomy being shielded from almost all human radio traffic. But such a mission could probably be automated.
Although samples returned from the Moon by Apollo have answered many questions concerning the makeup of the Moon and its history, there remains much to learn. Humans would be helpful in such a mission.
Allegedly ISRU on the Moon might be of use in providing propellant for space missions more cheaply than if supplied from Earth. This is debatable and in my opinion doubtful in the near term at least.
Recovery of oxygen from lunar regolith would require very high temperatures and use large amounts of power. Loading of large quantities of regolith into reactors and disposal of slag would not be trivial operations. It might be possible to make use of lunar polar water deposits, but the accessibility of these deposits is not entirely clear and they are located away from sources of solar power.
Even if propellants could be manufactured on the lunar surface they would suffer from significant overhead costs. All propellants generated would need to be lifted off of the surface using propellant in the process. The transfer vehicles would need to be returned to and landed back on the Moon also using propellants. Significant amounts of equipment such as solar arrays, tractors, habitats, furnaces and processing plants would be required. These would use propellant when landed on the surface and would probably require human intervention in their set up and maintenance using even more propellant.
The Moon has also been proposed as a suitable training ground for future Mars missions, but is likely to be of limited value in this respect. Mars has a 24 hour day, the Moon has a 336 hour day, Mars has an atmosphere, and the Moon has none. ISRU requirements would be very different on the Moon compared to Mars etc.