Changing gravity level can be a problem for flows of fluids, gasses, heat and for structural loads. Much equipment designed for Earth gravity fail in microgravity (even light bulbs and ballpoint pens).
But how is it the other way around? Do microgravity life support systems in general work also at 1g, maybe simply because it is practical for manufacturing and testing them? Is for example the ISS reliant on life support systems which would not work if we built a copy of the ISS on Earth' surface? And the same for the space shuttle, could a crew have spent a week inside it in 1g? (Consider only difference in gravity, no other environmental factors).
ADDITION: Would the coriolis effect and gradient of acceleration in a centrifuge or rotating spacecraft cause significant problems to mechanical equipment, such as flows of heat and fluids and moving parts?