This answer points out that the Space Shuttle's cabin atmosphere was designed to be equivalent to sea level air, in terms of both total pressure and oxygen partial pressure. However, could any of the Shuttle simulators emulate a different pressure or composition for the cabin atmosphere?
I'm specifically interested in Shuttle simulators (especially the ones described and pictured in this answer), not spacesuits (which have a different atmosphere that is explained in another question), nor general training facilities which have no resemblance to the Shuttle.